Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case‐control study

S. Fiandaca, Massimo; Kapogiannis, Dimitrios; Mapstone, Mark; L. Boxer, Adam; Eitan, Erez; B. Schwartz, Janice; L. Abner, Erin; C. Petersen, Ronald; J. Federoff, Howard; L. Miller, Bruce; J. Goetzl, Edward

doi:10.1016/j.jalz.2014.06.008

Public

Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case‐control study

Published in Alzheimer s & Dementia • Aug 14, 2014

Authors:

Massimo S. Fiandaca

Dimitrios Kapogiannis

Mark Mapstone

Abstract

BACKGROUND: Proteins pathogenic in Alzheimer's disease (AD) were extracted from neurally derived blood exosomes and quantified to develop biomarkers for the staging of sporadic AD. METHODS: Blood exosomes obtained at one time-point from patients with AD (n = 57) or frontotemporal dementia (FTD) (n =...

Subject

Microvesicles

Identification (biology)

Disease

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