Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case‐control study

S. Fiandaca, Massimo; Kapogiannis, Dimitrios; Mapstone, Mark; Boxer, Adam; Eitan, Erez; B. Schwartz, Janice; L. Abner, Erin; C. Petersen, Ronald; J. Federoff, Howard; L. Miller, Bruce; J. Goetzl, Edward

doi:10.1016/j.jalz.2014.06.008

Public

Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case‐control study

Shared by NobleBlocks on Aug 14, 2014 • 12:00 AM UTC

Authors:

Massimo S. Fiandaca

Dimitrios Kapogiannis

Mark Mapstone

Abstract

Abstract Background Proteins pathogenic in Alzheimer's disease (AD) were extracted from neurally derived blood exosomes and quantified to develop biomarkers for the staging of sporadic AD. Methods Blood exosomes obtained at one time‐point from patients with AD (n = 57) or frontotemporal dementia (FT...

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