ABCB1 and cytochrome P450 genotypes and phenotypes: Influence on methadone plasma levels and response to treatment

Crettol, Séverine; Déglon, Julien; Besson, Jacques; Croquette-Krokar, Marina; Hämmig, Robert; Gothuey, Isabelle; Monnat, Martine; B. Eap, Chin

doi:10.1016/j.clpt.2006.09.012

Public

ABCB1 and cytochrome P450 genotypes and phenotypes: Influence on methadone plasma levels and response to treatment

Published in Clinical Pharmacology & Therapeutics • Dec 1, 2006

Authors:

Séverine Crettol

Julien Déglon

Jacques Besson

Abstract

BACKGROUND AND OBJECTIVE: The in vivo implication of various cytochrome P450 (CYP) isoforms and of P-glycoprotein on methadone kinetics is unclear. We aimed to thoroughly examine the genetic factors influencing methadone kinetics and response to treatment. METHODS: Genotyping for CYP1A2, CYP2B6, CYP...

Subject

CYP2B6

Methadone

CYP3A

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