The Safety and Efficacy of Infliximab in Moderate to Severe Chronic Obstructive Pulmonary Disease

I. Rennard, Stephen; Fogarty, Charles; G. Kelsen, Steven; Long, W.A.; Ramsdell, Joe; E. Allison, James; A. Mahler, Donald; Saadeh, Constantine; M. Siler, Thomas; Snell, Phillip; E. Korenblat, Phillip; Smith, William; Kaye, Mitchell; Mandel, M.; P. Andrews, Charles; D. Prabhu, Rachakonda; F. Donohue, James; Watt, Rosemary; Hung Lo, Kim; Schlenker‐Herceg, Rozsa; S. Barnathan, Elliot; Murray, John

doi:10.1164/rccm.200607-995oc

Public

The Safety and Efficacy of Infliximab in Moderate to Severe Chronic Obstructive Pulmonary Disease

Published in American Journal of Respiratory and Critical Care Medicine • Feb 8, 2007

Authors:

Stephen I. Rennard

Charles Fogarty

Steven G. Kelsen

Abstract

RATIONALE: Chronic obstructive pulmonary disease (COPD) is a progressive, smoking-related, inflammatory lung disease in which tumor necrosis factor-alpha is overexpressed and has been suggested to play a pathogenic role. OBJECTIVES: To determine if infliximab, an anti-TNF-alpha antibody, results in ...

Subject

Medicine

Infliximab

Internal medicine

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