Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor ? monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis

N. Maini, Ravinder; C. Breedveld, Ferdinand; R. Kalden, Joachim; S Smolen, Josef; Davis, Diana; D. Macfarlane, J.; Antoni, Christian; F. Leeb, Burkhard; J. Elliott, Michael; N. Woody, James; Schaible, T; Feldmann, Marc

doi:10.1002/1529-0131(199809)41:9<1552::aid-art5>3.0.co;2-w

Public

Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor ? monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis

Published in Arthritis & Rheumatism • Sep 1, 1998

Authors:

Ravinder N. Maini

Ferdinand C. Breedveld

Joachim R. Kalden

Abstract

OBJECTIVE: To evaluate the efficacy, pharmacokinetics, immunogenicity, and safety of multiple infusions of a chimeric monoclonal anti-tumor necrosis factor alpha antibody (cA2) (infliximab; Remicade, Centocor, Malvern, PA) given alone or in combination with low-dose methotrexate (MTX) in rheumatoid ...

Subject

Medicine

Placebo

Rheumatoid arthritis

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