Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

C. Hait, Nitai; C. Allegood, Jeremy; Maceyka, Michael; M. Strub, Graham; B. Harikumar, Kuzhuvelil; K. Singh, Sandeep; Luo, Cheng; Marmorstein, Ronen; Kordula, Tomasz; Milstien, Sheldon; Spiegel, Sarah

doi:10.1126/science.1176709

Public

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

Published in Science • Sep 3, 2009

Authors:

Nitai C. Hait

Jeremy C. Allegood

Michael Maceyka

Abstract

The pleiotropic lipid mediator sphingosine-1-phosphate (S1P) can act intracellularly independently of its cell surface receptors through unknown mechanisms. Sphingosine kinase 2 (SphK2), one of the isoenzymes that generates S1P, was associated with histone H3 and produced S1P that regulated histone ...

Subject

Acetylation

Histone

Sphingosine-1-phosphate

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