Neuroprotective signal transduction in model motor neurons exposed to thrombin: G‐protein modulation effects on neurite outgrowth, Ca<sup>2+</sup> mobilization, and apoptosis

V. Smirnova, Irina; A. Citron, Bruce; M. Arnold, Paul; W. Festoff, Barry

doi:10.1002/neu.1044

Public

Neuroprotective signal transduction in model motor neurons exposed to thrombin: G‐protein modulation effects on neurite outgrowth, Ca2+ mobilization, and apoptosis

Published in Journal of Neurobiology • Jun 28, 2001

Authors:

Irina V. Smirnova

Bruce A. Citron

Paul M. Arnold

Abstract

Thrombin, the ultimate protease in the blood coagulation cascade, mediates its known cellular effects by unique proteolytic activation of G-protein-coupled protease-activated receptors (PARs), such as PAR1, PAR3, and PAR4, and a "tethered ligand" mechanism. PAR1 is variably expressed in subpopulatio...

Subject

Neuroprotection

Neurite

Biology

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