MicroRNA Microarray Identifies <i>Let-7i</i> as a Novel Biomarker and Therapeutic Target in Human Epithelial Ovarian Cancer

Yang, Nuo; Kaur, Sippy; Volinia, Stefano; Greshock, Joel; Lassus, Heini; Hasegawa, Kosei; Liang, Shun; Leminen, Arto; Deng, Shan; Smith, Lori; N. Johnstone, Cameron; Chen, Xian‐Ming; Liu, Chang‐Gong; Huang, Qihong; Katsaros, Dionyssios; A. Calin, George; Weber, Barbara; Bützow, Ralf; M. Croce, Carlo; Coukos, George; Zhang, Lin

doi:10.1158/0008-5472.can-08-1954

Public

MicroRNA Microarray Identifies Let-7i as a Novel Biomarker and Therapeutic Target in Human Epithelial Ovarian Cancer

Published in Cancer Research • Dec 15, 2008

Authors:

Nuo Yang

Sippy Kaur

Stefano Volinia

Abstract

MicroRNAs (miRNA) are approximately 22-nucleotide noncoding RNAs that negatively regulate protein-coding gene expression in a sequence-specific manner via translational inhibition or mRNA degradation. Our recent studies showed that miRNAs exhibit genomic alterations at a high frequency and their exp...

Subject

microRNA

Ovarian cancer

Biology

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