Comparison of Pioglitazone vs Glimepiride on Progression of Coronary Atherosclerosis in Patients With Type 2 Diabetes

E. Nissen, Steven; J. Nicholls, Stephen; Wolski, Kathy; W. Nesto, Richard; Kupfer, Stuart; Pérez, Alfonso; O. Jure, Horacio; De Larochellière, Robert; Staniloae, Cezar; Mavromatis, Kreton; Saw, Jacqueline; Hu, Bo; Michael Lincoff, A.; Murat Tuzcu, E.; the PERISCOPE Investigators, for

doi:10.1001/jama.299.13.1561

Public

Comparison of Pioglitazone vs Glimepiride on Progression of Coronary Atherosclerosis in Patients With Type 2 Diabetes

Published in JAMA • Apr 1, 2008

Authors:

Steven E. Nissen

Stephen J. Nicholls

Kathy Wolski

Abstract

CONTEXT: No antidiabetic regimen has demonstrated the ability to reduce progression of coronary atherosclerosis. Commonly used oral glucose-lowering agents include sulfonylureas, which are insulin secretagogues, and thiazolidinediones, which are insulin sensitizers. OBJECTIVE: To compare the effects...

Subject

Pioglitazone

Glimepiride

Medicine

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