Effect of Estrogen on Pseudomonas Mucoidy and Exacerbations in Cystic Fibrosis

H. Chotirmall, Sanjay; G. J. Smith, Stephen; Gunaratnam, Cedric; Cosgrove, Sonya; D. Dimitrov, Borislav; O’Neill, Shane; J. Harvey, Brian; M. Greene, Catherine; G. McElvaney, Noel

doi:10.1056/nejmoa1106126

Public

Effect of Estrogen on Pseudomonas Mucoidy and Exacerbations in Cystic Fibrosis

Published in New England Journal of Medicine • May 20, 2012

Authors:

Sanjay H. Chotirmall

Stephen G. J. Smith

Cedric Gunaratnam

Abstract

BACKGROUND: Women with cystic fibrosis are at increased risk for mucoid conversion of Pseudomonas aeruginosa, which contributes to a sexual dichotomy in disease severity. METHODS: We evaluated the effects of estradiol and its metabolite estriol on P. aeruginosa in vitro and in vivo and determined th...

Subject

Pseudomonas aeruginosa

Cystic fibrosis

Estriol

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