F8 gene mutation type and inhibitor development in patients with severe hemophilia A: systematic review and meta-analysis

C. Gouw, Samantha; Marijke van den Berg, H.; Oldenburg, Johannes; Astermark, Jan; G. de Groot, Philip; Margaglione, Maurizio; R. Thompson, Arthur; L. van Heerde, Waander; C. A. Boekhorst, J.; H. Miller, Connie; le Cessie, Saskia; G. van der Bom, Johanna

doi:10.1182/blood-2011-09-379453

Public

F8 gene mutation type and inhibitor development in patients with severe hemophilia A: systematic review and meta-analysis

Published in Blood • Jan 27, 2012

Authors:

Samantha C. Gouw

H. Marijke van den Berg

Johannes Oldenburg

Abstract

This systematic review was designed to provide more precise effect estimates of inhibitor development for the various types of F8 gene mutations in patients with severe hemophilia A. The primary outcome was inhibitor development and the secondary outcome was high-titer-inhibitor development. A syste...

Subject

Internal medicine

Odds ratio

Missense mutation

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