TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

Kleinberger, Gernot; Yamanishi, Yoshinori; Suárez‐Calvet, Marc; Czirr, Eva; Lohmann, Ebba; Cuyvers, Elise; Struyfs, Hanne; Pettkus, Nadine; Wenninger-Weinzierl, Andrea; Mazaheri, Fargol; Tahirović, Sabina; Lleó, Alberto; Alcolea, Daniel; Fortea, Juan; Willem, Michael; Lammich, Sven; Luís Molinuevo, José; Sánchez‐Valle, Raquel; Antonell, Anna; Ramı́rez, Alfredo; T. Heneka, Michael; Sleegers, Kristel; van der Zee, Julie; Martin, Jean‐Jacques; Engelborghs, Sebastiaan; Demirtaş-Tatlıdede, Aslı; Zetterberg, Henrik; Van Broeckhoven, Christine; Gürvıt, Hakan; Wyss‐Coray, Tony; Hardy, John; Colonna, Marco; Haass, Christian

doi:10.1126/scitranslmed.3009093

Public

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

Published in Science Translational Medicine • Jul 2, 2014

Authors:

Gernot Kleinberger

Yoshinori Yamanishi

Marc Suárez‐Calvet

Abstract

Genetic variants in the triggering receptor expressed on myeloid cells 2 (TREM2) have been linked to Nasu-Hakola disease, Alzheimer's disease (AD), Parkinson's disease, amyotrophic lateral sclerosis, frontotemporal dementia (FTD), and FTD-like syndrome without bone involvement. TREM2 is an innate im...

Subject

Neurodegeneration

Phagocytosis

TREM2

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