TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

Kleinberger, Gernot; Yamanishi, Yoshinori; Suárez-Calvet, Marc; Czirr, Eva; Lohmann, Ebba; Cuyvers, Elise; Struyfs, Hanne; Pettkus, Nadine; Wenninger-Weinzierl, Andrea; Mazaheri, Fargol; Tahirovic, Sabina; Lleó, Alberto; Alcolea, Daniel; Fortea, Juan; Willem, Michael; Lammich, Sven; L. Molinuevo, José; Sánchez-Valle, Raquel; Antonell, Anna; Ramirez, Alfredo; T. Heneka, Michael; Sleegers, Kristel; van der Zee, Julie; Martin, Jean-Jacques; Engelborghs, Sebastiaan; Demirtas-Tatlidede, Asli; Zetterberg, Henrik; Van Broeckhoven, Christine; Gurvit, Hakan; Wyss-Coray, Tony; Hardy, John; Colonna, Marco; Haass, Christian

doi:10.1126/scitranslmed.3009093

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TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

Shared by NobleBlocks on Jul 2, 2014 • 12:00 AM UTC

Authors:

Gernot Kleinberger

Yoshinori Yamanishi

Marc Suárez-Calvet

Abstract

Loss of TREM2 function impairs phagocytosis and correlates with decreased soluble TREM2 in biological fluids of patients with neurodegenerative disorders.

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