A randomized comparative trial of tenofovir DF or abacavir as replacement for a thymidine analogue in persons with lipoatrophy.

GJ, Moyle; CA, Sabin; J, Cartledge; M, Johnson; E, Wilkins; D, Churchill; P, Hay; A, Fakoya; M, Murphy; G, Scullard; C, Leen; G, Reilly

doi:10.1097/01.aids.0000247574.33998.03

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A randomized comparative trial of tenofovir DF or abacavir as replacement for a thymidine analogue in persons with lipoatrophy.

Shared by NobleBlocks on Oct 1, 2006 • 12:00 AM UTC

Authors:

Moyle GJ

Sabin CA

Cartledge J

Abstract

Background Long-term antiretroviral therapy, while dramatically reducing HIV-related morbidity and mortality, is associated with metabolic and morphological changes. Peripheral fat loss, lipoatrophy, appears most associated with prolonged therapy with thymidine nucleoside analogues.Methods A randomi...

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