A randomized comparative trial of tenofovir DF or abacavir as replacement for a thymidine analogue in persons with lipoatrophy

Moyle, Graeme; Sabin, Caroline; Cartledge, Jonathan; Johnson, Margaret; Wilkins, Edmund; Churchill, Duncan; Hay, P; Fakoya, Ade; Lois Murphy, M.; Scullard, G; Leen, Clifford; Reilly, Geraldine

doi:10.1097/01.aids.0000247574.33998.03

Public

A randomized comparative trial of tenofovir DF or abacavir as replacement for a thymidine analogue in persons with lipoatrophy

Published in AIDS • Oct 18, 2006

Authors:

Graeme Moyle

Caroline Sabin

Jonathan Cartledge

Abstract

BACKGROUND: Long-term antiretroviral therapy, while dramatically reducing HIV-related morbidity and mortality, is associated with metabolic and morphological changes. Peripheral fat loss, lipoatrophy, appears most associated with prolonged therapy with thymidine nucleoside analogues. METHODS: A rand...

Subject

Abacavir

Lipoatrophy

Medicine

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