Activation of Mitochondria and Release of Mitochondrial Apoptogenic Factors by Betulinic Acid

Different classes of anticancer drugs may trigger apoptosis by acting on different subcellular targets and by activating distinct signaling pathways. Here, we report that betulinic acid (BetA) is a prototype cytotoxic agent that triggers apoptosis by a direct effect on mitochondria. In isolated mito... View More