Induction of Epithelial–Mesenchymal Transition in Primary Airway Epithelial Cells from Patients with Asthma by Transforming Growth Factor-β1

Hackett, Tillie‐Louise; Warner, Stephanie; Stefanowicz, Dorota; Shaheen, Furquan; V. Pechkovsky, Dmitri; A. Murray, Lynne; L. Argentieri, Rochelle; Kicic, Anthony; M. Stick, Stephen; R. Bai, Tony; A. Knight, Darryl

doi:10.1164/rccm.200811-1730oc

Public

Induction of Epithelial–Mesenchymal Transition in Primary Airway Epithelial Cells from Patients with Asthma by Transforming Growth Factor-β1

Published in American Journal of Respiratory and Critical Care Medicine • Apr 30, 2009

Authors:

Tillie‐Louise Hackett

Stephanie Warner

Dorota Stefanowicz

Abstract

RATIONALE: Airway remodeling in asthma is associated with the accumulation of fibroblasts, the primary cell responsible for synthesis and secretion of extracellular matrix proteins. The process by which the number of fibroblasts increases in asthma is poorly understood, but epithelial-mesenchymal tr...

Subject

Epithelial–mesenchymal transition

Vimentin

Fibronectin

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