Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure

Boomer, Jonathan; To, Kathleen; Chang, Kathy; Takasu, Osamu; F. Osborne, Dale; H. Walton, Andrew; L. Bricker, Traci; Jarman, Stephen; Kreisel, Daniel; S. Krupnick, Alexander; Srivastava, Anil; E. Swanson, Paul; M. Green, Jonathan; S. Hotchkiss, Richard

doi:10.1001/jama.2011.1829

Public

Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure

Published in JAMA • Dec 20, 2011

Authors:

Jonathan Boomer

Kathleen To

Kathy Chang

Abstract

CONTEXT: Severe sepsis is typically characterized by initial cytokine-mediated hyperinflammation. Whether this hyperinflammatory phase is followed by immunosuppression is controversial. Animal studies suggest that multiple immune defects occur in sepsis, but data from humans remain conflicting. OBJE...

Subject

Medicine

Sepsis

Immunosuppression

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