TMEM16B, A Novel Protein with Calcium-Dependent Chloride Channel Activity, Associates with a Presynaptic Protein Complex in Photoreceptor Terminals

Stöhr, Heidi; Heisig, Julia; Benz, P.; Schöberl, Simon; M. Milenkovic, Vladimir; Strauß, Olaf; M. Aartsen, Wendy; Wijnholds, Jan; H. F. Weber, Bernhard; L. Schulz, Heidi

doi:10.1523/jneurosci.5546-08.2009

Public

TMEM16B, A Novel Protein with Calcium-Dependent Chloride Channel Activity, Associates with a Presynaptic Protein Complex in Photoreceptor Terminals

Published in Journal of Neuroscience • May 27, 2009

Authors:

Heidi Stöhr

Julia Heisig

P. Benz

Abstract

Photoreceptor ribbon synapses release glutamate in response to graded changes in membrane potential evoked by vast, logarithmically scalable light intensities. Neurotransmitter release is modulated by intracellular calcium levels. Large Ca(2+)-dependent chloride currents are important regulators of ...

Subject

PDZ domain

Ribbon synapse

Biology

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