Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation

H. Boudreau, Luc; Duchez, Anne‐Claire; Cloutier, Nathalie; Soulet, Denis; Martin, Nicolas; M. Bollinger, James; Paré, Alexandre; Rousseau, Matthieu; S. Naika, Gajendra; Lévesque, Tania; Laflamme, Cynthia; Marcoux, Geneviève; Lambeau, Gérard; W. Farndale, Richard; Pouliot, Marc; Hamzeh‐Cognasse, Hind; Cognasse, Fabrice; Garraud, Olivier; A. Nigrović, Peter; Guderley, Helga; Lacroix, Steve; Thibault, Louis; W. Semple, John; H. Gelb, Michael; Boilard, Éric

doi:10.1182/blood-2014-05-573543

Public

Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation

Published in Blood • Aug 1, 2014

Authors:

Luc H. Boudreau

Anne‐Claire Duchez

Nathalie Cloutier

Abstract

Mitochondrial DNA (mtDNA) is a highly potent inflammatory trigger and is reportedly found outside the cells in blood in various pathologies. Platelets are abundant in blood where they promote hemostasis. Although lacking a nucleus, platelets contain functional mitochondria. On activation, platelets ...

Subject

Inflammation

Platelet

Mitochondrion

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