NKp44L expression on CD4+ T cells is associated with impaired immunological recovery in HIV-infected patients under highly active antiretroviral therapy

Sennepin, Alexis; Baychelier, Florence; Guihot, Amélie; Nel, Isabelle; Ho Tsong Fang, Raphaël; Câlin, Ruxandra; Katlama, Christine; Simon, Anne; Crouzet, Joël; Debré, Patrice; Vieillard, Vincent

doi:10.1097/qad.0b013e328361a3fe

Public

NKp44L expression on CD4+ T cells is associated with impaired immunological recovery in HIV-infected patients under highly active antiretroviral therapy

Published in AIDS • Apr 17, 2013

Authors:

Alexis Sennepin

Florence Baychelier

Amélie Guihot

Abstract

OBJECTIVE: HIV-infected immunological nonresponders (InRs) patients fail to show satisfactory CD4+ T-cell recovery despite virologically effective HAART. We propose that NKp44L, the cellular ligand of an activating natural killer (NK) receptor, expressed only on uninfected bystander CD4+ T cells fro...

Subject

CD28

Immunology

Cytotoxic T cell

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