CCR5 deficiency exacerbates T-cell-mediated hepatitis in mice.

C, Moreno; T, Gustot; C, Nicaise; E, Quertinmont; N, Nagy; M, Parmentier; Moine O, Le; J, Devière; H, Louis

doi:10.1002/hep.20865

Public

CCR5 deficiency exacerbates T-cell-mediated hepatitis in mice.

Shared by NobleBlocks on Oct 1, 2005 • 12:00 AM UTC

Authors:

Moreno C

Gustot T

Nicaise C

Abstract

Experimental T-cell-mediated hepatitis induced by concanavalin A (Con A) involves the production of different cytokines and chemokines and is characterized by leukocyte infiltration. Because the chemokine receptor CCR5 and its ligands (CCL3, CCL4, and CCL5) regulate leukocyte chemotaxis and activati...

Discussions