GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies.

P. McEver, Rodger; H. Beckstead, Jay; L. Moore, Kevin; Marshall-Carlson, L; F Bainton, D

doi:10.1172/jci114175

Public

GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies.

Published in Journal of Clinical Investigation • Jul 1, 1989

Authors:

Rodger P. McEver

Jay H. Beckstead

Kevin L. Moore

Abstract

We used an immunoperoxidase procedure to examine the tissue distribution of the platelet alpha-granule membrane protein, GMP-140. In addition to its presence in megakaryocytes and platelets, GMP-140 antigen was found in vascular endothelial cells of diverse human organs, but it was not detected in o...

Subject

Umbilical vein

Platelet

Immunogold labelling

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