2-D Structure of the A Region of Xist RNA and Its Implication for PRC2 Association

Maenner, Sylvain; Blaud, Magali; Fouillen, Laëtitia; Savoye, Anne; Marchand, Virginie; Dubois, Agnès; Cianférani, Sarah; Van Dorsselaer, Alain; Clerc, Philippe; Avner, Philip; Visvikis, Athanase; Branlant, Christiane

doi:10.1371/journal.pbio.1000276

Public

2-D Structure of the A Region of Xist RNA and Its Implication for PRC2 Association

Published in PLoS Biology • Jan 4, 2010

Authors:

Sylvain Maenner

Magali Blaud

Laëtitia Fouillen

Abstract

In placental mammals, inactivation of one of the X chromosomes in female cells ensures sex chromosome dosage compensation. The 17 kb non-coding Xist RNA is crucial to this process and accumulates on the future inactive X chromosome. The most conserved Xist RNA region, the A region, contains eight or...

Subject

XIST

Biology

RNA

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