The Cystine/Glutamate Antiporter System x c − in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities

Lewerenz, Jan; J. Hewett, Sandra; Huang, Ying; P. Lambros, Maria; W. Gout, Peter; W. Kalivas, Peter; Massie, Ann; Smolders, Ilse; Methner, Axel; Pergande, Mathias; B. Smith, Sylvia; Ganapathy, Vadivel; Maher, Pamela

doi:10.1089/ars.2011.4391

Public

The Cystine/Glutamate Antiporter System x c − in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities

Published in Antioxidants and Redox Signaling • Jun 5, 2012

Authors:

Jan Lewerenz

Sandra J. Hewett

Ying Huang

Abstract

The antiporter system xc− imports the amino acid cystine, the oxidized form of cysteine, into cells with a 1:1 counter-transport of glutamate. It is composed of a light chain, xCT, and a heavy chain, 4F2 heavy chain (4F2hc), and, thus, belongs to the family of heterodimeric amino acid transporters. ...

Subject

Cystine

Antiporter

Cysteine

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