Effects of febuxostat versus allopurinol and placebo in reducing serum urate in subjects with hyperuricemia and gout: A 28‐week, phase III, randomized, double‐blind, parallel‐group trial

Ralph Schumacher, H.; A. Becker, Michael; L. Wortmann, Robert; MacDonald, Patricia; Hunt, Barbara; Streit, Janet; Lademacher, Christopher; Joseph‐Ridge, Nancy

doi:10.1002/art.24209

Public

Effects of febuxostat versus allopurinol and placebo in reducing serum urate in subjects with hyperuricemia and gout: A 28‐week, phase III, randomized, double‐blind, parallel‐group trial

Published in Arthritis Care & Research • Oct 30, 2008

Authors:

H. Ralph Schumacher

Michael A. Becker

Robert L. Wortmann

Abstract

OBJECTIVE: To compare the urate-lowering efficacy and safety of febuxostat, allopurinol, and placebo in a large group of subjects with hyperuricemia and gout, including persons with impaired renal function. METHODS: Subjects (n = 1,072) with hyperuricemia (serum urate level > or = 8.0 mg/dl) and gou...

Subject

Febuxostat

Hyperuricemia

Gout

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