Association of BRCA1 and BRCA2 Mutations With Survival, Chemotherapy Sensitivity, and Gene Mutator Phenotype in Patients With Ovarian Cancer

Yang, Da; Khan, Sofia; Sun, Yan; R. Hess, Kenneth; Shmulevich, Ilya; K. Sood, Anil; Zhang, Wei

doi:10.1001/jama.2011.1456

Public

Association of BRCA1 and BRCA2 Mutations With Survival, Chemotherapy Sensitivity, and Gene Mutator Phenotype in Patients With Ovarian Cancer

Published in JAMA • Oct 12, 2011

Authors:

Da Yang

Sofia Khan

Yan Sun

Abstract

CONTEXT: Attempts to determine the clinical significance of BRCA1/2 mutations in ovarian cancer have produced conflicting results. OBJECTIVE: To determine the relationships between BRCA1/2 deficiency (ie, mutation and promoter hypermethylation) and overall survival (OS), progression-free survival (P...

Subject

Medicine

Ovarian cancer

Oncology

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