Genomic Analysis of Non-
 NF2
 Meningiomas Reveals Mutations in
 TRAF7
 ,
 KLF4
 ,
 AKT1
 , and
 SMO

E. Clark, Victoria; Zeynep Erson-Omay, E.; Serin, Akdes; Yin, Jun; Cotney, Justin; Özduman, Koray; Avşar, Timuçin; Li, Jie; B. Murray, Phillip; Henegariu, Octavian; Yilmaz, Saliha; Moliterno Günel, Jennifer; Carrión-Grant, Geneive; Yılmaz, Baran; Grady, Conor; Tanrıkulu, Bahattin; Bakırcıoğlu, Mehmet; Kaymakçalan, Hande; Okay Caglayan, Ahmet; Sencar, Leman; Ceyhun, Emre; Fatih Atik, A.; Bayri, Yaşar; Bai, Hanwen; E. Kolb, Luis; M. Hebert, Ryan; Bulent Omay, S.; Mishra-Gorur, Ketu; Choi, Murim; D. Overton, John; C. Holland, Eric; Mane, Shrikant; W. State, Matthew; Bilgüvar, Kaya; M. Baehring, Joachim; H. Gutin, Philip; M. Piepmeier, Joseph; Vortmeyer, Alexander; W. Brennan, Cameron; Necmettin Pamir, M.; Kılıç, Türker; P. Lifton, Richard; P. Noonan, James; Yasuno, Katsuhito; Günel, Murat

doi:10.1126/science.1233009

Public

Genomic Analysis of Non- NF2 Meningiomas Reveals Mutations in TRAF7 , KLF4 , AKT1 , and SMO

Shared by NobleBlocks on Mar 1, 2013 • 12:00 AM UTC

Authors:

Victoria E. Clark

E. Zeynep Erson-Omay

Akdes Serin

Abstract

Genetic Clues to Meningioma Meningiomas are the most common primary brain tumors in adults. Located within the layer of tissue covering the brain, these tumors are usually slow-growing and benign but can cause serious neurological complications. About half of these tumors have mutations in the neuro...

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