Increased Gut Permeability and Microbiota Change Associate with Mesenteric Fat Inflammation and Metabolic Dysfunction in Diet-Induced Obese Mice

Y. Lam, Yan; Ha, Connie; Campbell, Craig; J. Mitchell, Andrew; Dinudom, Anuwat; Oscarsson, Jan; I. Cook, David; H. Hunt, Nicholas; D. Caterson, Ian; Holmes, Andrew; H. Storlien, L.

doi:10.1371/journal.pone.0034233

Public

Increased Gut Permeability and Microbiota Change Associate with Mesenteric Fat Inflammation and Metabolic Dysfunction in Diet-Induced Obese Mice

Published in PLoS ONE • Mar 23, 2012

Authors:

Yan Y. Lam

Connie Ha

Craig Campbell

Abstract

We investigated the relationship between gut health, visceral fat dysfunction and metabolic disorders in diet-induced obesity. C57BL/6J mice were fed control or high saturated fat diet (HFD). Circulating glucose, insulin and inflammatory markers were measured. Proximal colon barrier function was ass...

Subject

Insulin resistance

Internal medicine

Endocrinology

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