IRES-Dependent Second Gene Expression Is Significantly Lower Than Cap-Dependent First Gene Expression in a Bicistronic Vector

Mizuguchi, Hiroyuki; Xu, Zhili; Ishii‐Watabe, Akiko; Uchida, Eriko; Hayakawa, Takao

doi:10.1006/mthe.2000.0050

Public

IRES-Dependent Second Gene Expression Is Significantly Lower Than Cap-Dependent First Gene Expression in a Bicistronic Vector

Published in Molecular Therapy • Apr 1, 2000

Authors:

Hiroyuki Mizuguchi

Zhili Xu

Akiko Ishii‐Watabe

Abstract

The internal ribosome entry site (IRES) has been widely used to coexpress heterologous gene products by a message from a single promoter. However, little is known about the efficiency of IRES-dependent second gene expression in comparison with that of first gene expression. This study was undertaken...

Subject

Internal ribosome entry site

Biology

Gene expression

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