Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

Hsiao, Karen; Chapman, Paul; Nilsen, Steven; Eckman, Chris; Harigaya, Yasuo; Younkin, Steven; Yang, Fusheng; Cole, Greg

doi:10.1126/science.274.5284.99

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Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

Shared by NobleBlocks on Oct 4, 1996 • 12:00 AM UTC

Authors:

Karen Hsiao

Paul Chapman

Steven Nilsen

Abstract

Transgenic mice overexpressing the 695-amino acid isoform of human Alzheimer β-amyloid (Aβ) precursor protein containing a Lys 670 → Asn, Met 671 → Leu mutation had normal learning and memory in spatial reference and alternation tasks at 3 months of age but showed impairment by 9 to 10 months of age...

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