Novel Anti-Metastatic Action of Cidofovir Mediated by Inhibition of E6/E7, CXCR4 and Rho/ROCK Signaling in HPV+ Tumor Cells

Amine, Abdessamad; Rivera, Sofía; Opolon, Paule; Dekkal, Mehdi; Biard, Denis; Bouamar, Hakim; Louache, Fawzia; J. McKay, Michael; Bourhis, Jean; Deutsch, Éric; Vozenin, Marie‐Catherine

doi:10.1371/journal.pone.0005018

Public

Novel Anti-Metastatic Action of Cidofovir Mediated by Inhibition of E6/E7, CXCR4 and Rho/ROCK Signaling in HPV+ Tumor Cells

Published in PLoS ONE • Mar 25, 2009

Authors:

Abdessamad Amine

Sofía Rivera

Paule Opolon

Abstract

Cervical cancer is frequently associated with HPV infection. The expression of E6 and E7 HPV oncoproteins is a key factor in its carcinogenicity and might also influence its virulence, including metastatic conversion. The cellular mechanisms involved in metastatic spread remain elusive, but pro-adhe...

Subject

Cancer research

Metastasis

Matrigel

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!