The CroRS Two-Component Regulatory System Is Requiredfor Intrinsic β-Lactam Resistance in Enterococcusfaecalis

Enterococcus faecalis produces a specific penicillin-binding protein (PBP5) that mediates high-level resistance to the cephalosporin class of beta-lactam antibiotics. Deletion of a locus encoding a previously uncharacterized two-component regulatory system of E. faecalis (croRS) led to a 4,000-fold ... View More