IL-7 administration drives T cell–cycle entry and expansion in HIV-1 infection

Sereti, Irini; M. Dunham, Richard; Spritzler, John; Aga, Evgenia; A. Proschan, Michael; Medvik, Kathy; A. Battaglia, Catherine; Landay, Alan; Pahwa, Savita; A. Fischl, Margaret; M. Asmuth, David; R. Tenorio, Allan; D. Altman, John; Fox, Lawrence; Moir, Susan; Malaspina, Angela; Morre, Michel; Buffet, Renaud; Silvestri, Guido; M. Lederman, Michael

doi:10.1182/blood-2008-10-186601

Public

IL-7 administration drives T cell–cycle entry and expansion in HIV-1 infection

Published in Blood • Apr 20, 2009

Authors:

Irini Sereti

Richard M. Dunham

John Spritzler

Abstract

Interleukin 7 (IL-7) is a common gamma chain receptor cytokine implicated in thymopoiesis and in peripheral expansion and survival of T lymphocytes. The safety and activity of recombinant human IL-7 (rhIL-7) administration were therefore examined in HIV-infected persons. In this prospective randomiz...

Subject

Interleukin-7 receptor

IL-2 receptor

CD8

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