Overexpression of 11β‐hydroxysteroid dehydrogenase type 1 in visceral adipose tissue and portal hypercortisolism in non‐alcoholic fatty liver disease

Cândia, Roberto; Riquelme, Arnoldo; Baudrand, René; A. Carvajal, Cristián; Morales, Mauricio; Solı́s, Nancy; Pizarro, Margarita; Escalona, Alex; Carrasco-Aviño, Gonzalo; Boza, Camilo; Pérez, Gustavo; Padilla, Oslando; Cerda, Jaime; Fardella, Carlos; Arrese, Marco

doi:10.1111/j.1478-3231.2011.02685.x

Public

Overexpression of 11β‐hydroxysteroid dehydrogenase type 1 in visceral adipose tissue and portal hypercortisolism in non‐alcoholic fatty liver disease

Published in Liver International • Dec 4, 2011

Authors:

Roberto Cândia

Arnoldo Riquelme

René Baudrand

Abstract

BACKGROUND: The enzyme 11β-hydroxysteroid-dehydrogenase type 1 (11β-HSD1) catalyses the reactivation of intracellular cortisol. We explored the potential role of 11β-HSD1 overexpression in visceral adipose tissue (VAT) in non-alcoholic fatty liver disease (NAFLD) assessing sequential changes of enzy...

Subject

11β-hydroxysteroid dehydrogenase type 1

Internal medicine

Adipose tissue

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