Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is responsible for the prevention of colitis-associated cancer

Guo, Wenjie; Sun, Yang; Liu, Wen; Wu, Xingxin; Guo, Lele; Cai, Peifen; Wu, Xuefeng; Wu, Xudong; Shen, Yan; Shu, Yongqian; Gu, Yanhong; Xu, Qiang

doi:10.4161/auto.28374

Public

Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is responsible for the prevention of colitis-associated cancer

Published in Autophagy • Apr 1, 2014

Authors:

Wenjie Guo

Yang Sun

Wen Liu

Abstract

Nonresolving inflammation in the intestine predisposes individuals to the development of colitis-associated cancer (CAC). Inflammasomes are thought to mediate intestinal homeostasis, and their dysregulation contributes to inflammatory bowel diseases and CAC. However, few agents have been reported to...

Subject

Inflammasome

Azoxymethane

Mitophagy

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!