MicroRNA-125b Confers the Resistance of Breast Cancer Cells to Paclitaxel through Suppression of Pro-apoptotic Bcl-2 Antagonist Killer 1 (Bak1) Expression

Zhou, Ming; Liu, Zixing; Zhao, Yuhua; Ding, Yan; Liu, Hao; Xi, Yaguang; Xiong, Wei; Li, Guiyuan; Lu, Jianrong; Fodstad, Øystein; I. Riker, Adam; Tan, Ming

doi:10.1074/jbc.m109.083337

Public

MicroRNA-125b Confers the Resistance of Breast Cancer Cells to Paclitaxel through Suppression of Pro-apoptotic Bcl-2 Antagonist Killer 1 (Bak1) Expression

Published in Journal of Biological Chemistry • May 12, 2010

Authors:

Ming Zhou

Zixing Liu

Yuhua Zhao

Abstract

Paclitaxel (Taxol) is an effective chemotherapeutic agent for treatment of cancer patients. Despite impressive initial clinical responses, the majority of patients eventually develop some degree of resistance to Taxol-based therapy. The mechanisms underlying cancer cells resistance to Taxol are not ...

Subject

Paclitaxel

microRNA

Apoptosis

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