Regulation of Transforming Growth Factor-β1–driven Lung Fibrosis by Galectin-3

C. MacKinnon, Alison; Gibbons, Michael; L. Farnworth, Sarah; Leffler, Hakon; J. Nilsson, Ulf; Delaine, Tamara; John Simpson, A.; J. Forbes, Stuart; Hirani, Nik; Gauldie, Jack; Sethi, Tariq

doi:10.1164/rccm.201106-0965oc

Public

Regulation of Transforming Growth Factor-β1–driven Lung Fibrosis by Galectin-3

Published in American Journal of Respiratory and Critical Care Medicine • Nov 18, 2011

Authors:

Alison C. MacKinnon

Michael Gibbons

Sarah L. Farnworth

Abstract

RATIONALE: Idiopathic pulmonary fibrosis (IPF) is a chronic dysregulated response to alveolar epithelial injury with differentiation of epithelial cells and fibroblasts into matrix-secreting myofibroblasts resulting in lung scaring. The prognosis is poor and there are no effective therapies or relia...

Subject

Idiopathic pulmonary fibrosis

Galectin-3

Medicine

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