Clinical Relevance of Cortical Spreading Depression in Neurological Disorders: Migraine, Malignant Stroke, Subarachnoid and Intracranial Hemorrhage, and Traumatic Brain Injury

Lauritzen, Martin; P. Dreier, Jens; Fabricius, Martin; A. Hartings, Jed; Graf, Rudolf; J. Strong, Anthony

doi:10.1038/jcbfm.2010.191

Public

Clinical Relevance of Cortical Spreading Depression in Neurological Disorders: Migraine, Malignant Stroke, Subarachnoid and Intracranial Hemorrhage, and Traumatic Brain Injury

Published in Journal of Cerebral Blood Flow & Metabolism • Nov 3, 2010

Authors:

Martin Lauritzen

Jens P. Dreier

Martin Fabricius

Abstract

Cortical spreading depression (CSD) and depolarization waves are associated with dramatic failure of brain ion homeostasis, efflux of excitatory amino acids from nerve cells, increased energy metabolism and changes in cerebral blood flow (CBF). There is strong clinical and experimental evidence to s...

Subject

Cortical spreading depression

Traumatic brain injury

Subarachnoid hemorrhage

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