Identification of Chimeric Antigen Receptors That Mediate Constitutive or Inducible Proliferation of T Cells

Abstract This study compared second-generation chimeric antigen receptors (CAR) encoding signaling domains composed of CD28, ICOS, and 4-1BB (TNFRSF9). Here, we report that certain CARs endow T cells with the ability to undergo long-term autonomous proliferation. Transduction of primary human T cell... View More