Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis

Neumann, Manuela; M. Sampathu, Deepak; K. Kwong, Linda; C. Truax, Adam; C. Micsenyi, Matthew; T. Chou, Thomas; Bruce, Jennifer; Schuck, Theresa; Grossman, Murray; M. Clark, Christopher; McCluskey, Leo; L. Miller, Bruce; Masliah, Eliezer; R. Mackenzie, Ian; Feldman, Howard; Feiden, W.; A. Kretzschmar, Hans; Q. Trojanowski, John; M.‐Y. Lee, Virginia

doi:10.1126/science.1134108

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Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis

Published in Science • Oct 5, 2006

Authors:

Manuela Neumann

Deepak M. Sampathu

Linda K. Kwong

Abstract

Ubiquitin-positive, tau- and alpha-synuclein-negative inclusions are hallmarks of frontotemporal lobar degeneration with ubiquitin-positive inclusions and amyotrophic lateral sclerosis. Although the identity of the ubiquitinated protein specific to either disorder was unknown, we showed that TDP-43 ...

Subject

Amyotrophic lateral sclerosis

Frontotemporal lobar degeneration

Ubiquitin

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