<i>CCAT2</i>, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer

Ling, Hui; Spizzo, Riccardo; Atlasi, Yaser; S. Nicoloso, Milena; Shimizu, Masayoshi; S. Redis, Roxana; Nishida, Naohiro; Gafà, Roberta; H. Song, Jian; Guo, Zhiyi; Ivan, Cristina; Barbarotto, Elisa; de Vries, Ingrid; Zhang, Xinna; Ferracin, Manuela; Churchman, Mike; F. van Galen, Janneke; Beverloo, Berna; Shariati, Maryam; Haderk, Franziska; R. Estecio, Marcos; Garcia‐Manero, Guillermo; A. Patijn, Gijs; C. Gotley, D.; Bhardwaj, Vikas; Shureiqi, Imad; Sen, Subrata; S. Multani, Asha; Welsh, James; Yamamoto, Ken; Taniguchi, Itsuki; Song, Min‐Ae; Gallinger, Steven; Casey, Graham; N. Thibodeau, Stephen; Le Marchand, Loı̈c; Tiirikainen, Maarit; A. Mani, Sendurai; Zhang, Wei; V. Davuluri, Ramana; Mimori, Koshi; Mori, Masaki; M. Sieuwerts, Anieta; W.M. Martens, John; Tomlinson, Ian; Negrini, Massimo; Berindan‐Neagoe, Ioana; A. Foekens, John; R. Hamilton, Stanley; Lanza, Giovanni; Kopetz, Scott; Fodde, Riccardo; A. Călin, George

doi:10.1101/gr.152942.112

Public

CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer

Published in Genome Research • Jun 24, 2013

Authors:

Hui Ling

Riccardo Spizzo

Yaser Atlasi

Abstract

The functional roles of SNPs within the 8q24 gene desert in the cancer phenotype are not yet well understood. Here, we report that CCAT2, a novel long noncoding RNA transcript (lncRNA) encompassing the rs6983267 SNP, is highly overexpressed in microsatellite-stable colorectal cancer and promotes tum...

Subject

Biology

Wnt signaling pathway

Long non-coding RNA

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