Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia

L. Fisher, Cynthia; Pineault, Nicolas; Brookes, Christy; D. Helgason, Cheryl; Ohta, Hideaki; Bodner, Caroline; L. Hess, Jay; Keith Humphries, R.; W. Brock, Hugh

doi:10.1182/blood-2009-07-230698

Public

Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia

Published in Blood • Oct 28, 2009

Authors:

Cynthia L. Fisher

Nicolas Pineault

Christy Brookes

Abstract

The Additional sex combs like 1 (Asxl1) gene is 1 of 3 mammalian homologs of the Additional sex combs (Asx) gene of Drosophila. Asx is unusual because it is required to maintain both activation and silencing of Hox genes in flies and mice. Asxl proteins are characterized by an amino terminal homolog...

Subject

Biology

Chronic myelomonocytic leukemia

Haematopoiesis

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