Computational Model of the HIV-1 Subtype A V3 Loop: Study on the Conformational Mobility for Structure-Based Anti-AIDS Drug Design

M. Andrianov, Alexander; Anishchenko, Ivan

doi:10.1080/07391102.2009.10507308

Public

Computational Model of the HIV-1 Subtype A V3 Loop: Study on the Conformational Mobility for Structure-Based Anti-AIDS Drug Design

Published in Journal of Biomolecular Structure and Dynamics • Oct 1, 2009

Authors:

Alexander M. Andrianov

Ivan Anishchenko

Abstract

The V3 loop of the HIV-1gp120 glycoprotein presenting 35-residue-long, frequently glycosylated, highly variable, and disulfide bonded structure plays the central role in the virus biology and forms the principal target for neutralizing antibodies and the major viral determinant for co-receptor bindi...

Subject

V3 loop

Human immunodeficiency virus (HIV)

Protein structure

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