DNA Repair by ERCC1 in Non–Small-Cell Lung Cancer and Cisplatin-Based Adjuvant Chemotherapy

A. Olaussen, Ken; Dunant, Ariane; Fouret, Pierre; Brambilla, Élisabeth; André, Fabrice; Haddad, Vincent; Taranchon, E.; Filipits, Martin; Pirker, Robert; Popper, Helmut; A. Stahel, Rolf; Sabatier, Laure; Pignon, Jean‐Pierre; Tursz, Thomas; Le Chevalier, Thierry; Soria, Jean‐Charles

doi:10.1056/nejmoa060570

Public

DNA Repair by ERCC1 in Non–Small-Cell Lung Cancer and Cisplatin-Based Adjuvant Chemotherapy

Published in New England Journal of Medicine • Sep 6, 2006

Authors:

Ken A. Olaussen

Ariane Dunant

Pierre Fouret

Abstract

BACKGROUND: Adjuvant cisplatin-based chemotherapy improves survival among patients with completely resected non-small-cell lung cancer, but there is no validated clinical or biologic predictor of the benefit of chemotherapy. METHODS: We used immunohistochemical analysis to determine the expression o...

Subject

ERCC1

Medicine

Hazard ratio

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