Regulation of Protein Kinase B/Akt-Serine 473 Phosphorylation by Integrin-linked Kinase

Persad, Sujata; Attwell, Sarah; Gray, Virginia; M. Mawji, Nasrin; Deng, Jing; Leung, Dan; Yan, Jun; S. Sanghera, Jasbinder; P. Walsh, Michael; Dedhar, Shoukat

doi:10.1074/jbc.m102940200

Public

Regulation of Protein Kinase B/Akt-Serine 473 Phosphorylation by Integrin-linked Kinase

Published in Journal of Biological Chemistry • Jul 1, 2001

Authors:

Sujata Persad

Sarah Attwell

Virginia Gray

Abstract

Protein kinase B (PKB/Akt) is a regulator of cell survival and apoptosis. To become fully activated, PKB/Akt requires phosphorylation at two sites, threonine 308 and serine 473, in a phosphatidylinositol (PI) 3-kinase-dependent manner. The kinase responsible for phosphorylation of threonine 308 is t...

Subject

Integrin-linked kinase

Protein kinase B

AKT1

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