Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle

He, Weimin; Barak, Yaacov; L. Hevener, Andrea; Olson, Peter; Liao, Debbie; Le, Jamie; C. Nelson, Michael; S. Ong, Estelita; M. Olefsky, Jerrold; M. Evans, Ronald

doi:10.1073/pnas.2536828100

Public

Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle

Published in Proceedings of the National Academy of Sciences • Dec 5, 2003

Authors:

Weimin He

Yaacov Barak

Andrea L. Hevener

Abstract

Syndrome X, typified by obesity, insulin resistance (IR), dyslipidemia, and other metabolic abnormalities, is responsive to antidiabetic thiazolidinediones (TZDs). Peroxisome proliferator-activated receptor (PPAR) gamma, a target of TZDs, is expressed abundantly in adipocytes, suggesting an importan...

Subject

Endocrinology

Internal medicine

Insulin resistance

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