Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle.

W, He; Y, Barak; A, Hevener; P, Olson; D, Liao; J, Le; M, Nelson; E, Ong; JM, Olefsky; RM, Evans

doi:10.1073/pnas.2536828100

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Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle.

Shared by NobleBlocks on Dec 5, 2003 • 12:00 AM UTC

Authors:

He W

Barak Y

Hevener A

Abstract

Syndrome X, typified by obesity, insulin resistance (IR), dyslipidemia, and other metabolic abnormalities, is responsive to antidiabetic thiazolidinediones (TZDs). Peroxisome proliferator-activated receptor (PPAR) gamma, a target of TZDs, is expressed abundantly in adipocytes, suggesting an importan...

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