Therapeutic Benefit of Intravenous Administration of Bone Marrow Stromal Cells After Cerebral Ischemia in Rats

Chen, Jieli; Li, Yi; Wang, Lei; Zhang, Zhenggang; Lu, Dunyue; Lü, Mei; Chopp, Michael

doi:10.1161/01.str.32.4.1005

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Therapeutic Benefit of Intravenous Administration of Bone Marrow Stromal Cells After Cerebral Ischemia in Rats

Published in Stroke • Apr 1, 2001

Authors:

Jieli Chen

Yi Li

Lei Wang

Abstract

BACKGROUND AND PURPOSE: We tested the hypothesis that intravenous infusion of bone marrow derived-marrow stromal cells (MSCs) enter the brain and reduce neurological functional deficits after stroke in rats. METHODS: Rats (n=32) were subjected to 2 hours of middle cerebral artery occlusion (MCAO). T...

Subject

Medicine

Mesenchymal stem cell

Bone marrow

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