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                      <i>PKD2</i>
                    </b>
                    , a Gene for Polycystic Kidney Disease That Encodes an Integral Membrane Protein

Mochizuki, Toshio; Wu, Guanqing; Hayashi, Tomohito; L. Xenophontos, Stavroulla; Veldhuisen, Barbera; J. Saris, Jasper; M. Reynolds, David; Cai, Yiqiang; A. Gabow, Patricia; Pierides, Alkis; J. Kimberling, William; H. Breuning, Martijn; Constantinou Deltas, C.; J. M. Peters, Dorien; Somlo, Stefan

doi:10.1126/science.272.5266.1339

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PKD2 , a Gene for Polycystic Kidney Disease That Encodes an Integral Membrane Protein

Shared by NobleBlocks on May 28, 1996 • 12:00 AM UTC

Authors:

Toshio Mochizuki

Guanqing Wu

Tomohito Hayashi

Abstract

A second gene for autosomal dominant polycystic kidney disease was identified by positional cloning. Nonsense mutations in this gene ( PKD2 ) segregated with the disease in three PKD2 families. The predicted 968-amino acid sequence of the PKD2 gene product has six transmembrane spans with intracellu...

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