PERIOD1-Associated Proteins Modulate the Negative Limb of the Mammalian Circadian Oscillator

A. Brown, Steven; Ripperger, Juergen; Kadener, Sebastián; Fleury-Olela, Fabienne; Vilbois, Francis; Rosbash, Michael; Schibler, Ueli

doi:10.1126/science.1107373

Public

PERIOD1-Associated Proteins Modulate the Negative Limb of the Mammalian Circadian Oscillator

Published in Science • Apr 28, 2005

Authors:

Steven A. Brown

Juergen Ripperger

Sebastián Kadener

Abstract

The clock proteins PERIOD1 (PER1) and PERIOD2 (PER2) play essential roles in a negative transcriptional feedback loop that generates circadian rhythms in mammalian cells. We identified two PER1-associated factors, NONO and WDR5, that modulate PER activity. The reduction of NONO expression by RNA int...

Subject

PER1

PER2

Circadian rhythm

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