The urokinase-type plasminogen activator system in cancer metastasis: A review

A. Andreasen, Peter; Kjøller, Lars; Christensen, Lise; J. Duffy, Michael

doi:10.1002/(sici)1097-0215(19970703)72:1<1::aid-ijc1>3.0.co;2-z

Public

The urokinase-type plasminogen activator system in cancer metastasis: A review

Published in International Journal of Cancer • Jul 3, 1997

Authors:

Peter A. Andreasen

Lars Kjøller

Lise Christensen

Abstract

The urokinase-type plasminogen activator (u-PA) system consists of the serine proteinases plasmin and u-PA; the serpin inhibitors alpha2-anti-plasmin, PAI-1 and PAI-2; and the u-PA receptor (u-PAR). Two lines of evidence have strongly suggested an important and apparently causal role for the u-PA sy...

Subject

Metastasis

Plasmin

Plasminogen activator

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