Common Variants at 10 Genomic Loci Influence Hemoglobin A1C Levels via Glycemic and Nonglycemic Pathways

Soranzo, Nicole; Sanna, Serena; Wheeler, Eleanor; Gieger, Christian; Radke, Dörte; Dupuis, Josée; Bouatia-Naji, Nabila; Langenberg, Claudia; Prokopenko, Inga; Stolerman, Elliot; S. Sandhu, Manjinder; M. Heeney, Matthew; M. Devaney, Joseph; P. Reilly, Muredach; L. Ricketts, Sally

doi:10.2337/db10-0502

Public

Common Variants at 10 Genomic Loci Influence Hemoglobin A1C Levels via Glycemic and Nonglycemic Pathways

Shared by NobleBlocks on Sep 21, 2010 • 12:00 AM UTC

Authors:

Nicole Soranzo

Serena Sanna

Eleanor Wheeler

Abstract

OBJECTIVE Glycated hemoglobin (HbA1c), used to monitor and diagnose diabetes, is influenced by average glycemia over a 2- to 3-month period. Genetic factors affecting expression, turnover, and abnormal glycation of hemoglobin could also be associated with increased levels of HbA1c. We aimed to ident...

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