Common Variants at 10 Genomic Loci Influence Hemoglobin A1C Levels via Glycemic and Nonglycemic Pathways

Soranzo, Nicole; Sanna, Serena; Wheeler, Eleanor; Gieger, Christian; Radke, Dörte; Dupuis, Josée; Bouatia‐Naji, Nabila; Langenberg, Claudia; Prokopenko, Inga; Stolerman, Elliot; S. Sandhu, Manjinder; M. Heeney, Matthew; M. Devaney, Joseph; P. Reilly, Muredach; L. Ricketts, Sally

doi:10.2337/db10-0502

Public

Common Variants at 10 Genomic Loci Influence Hemoglobin A1C Levels via Glycemic and Nonglycemic Pathways

Published in Diabetes • Sep 21, 2010

Authors:

Nicole Soranzo

Serena Sanna

Eleanor Wheeler

Abstract

OBJECTIVE: Glycated hemoglobin (HbA₁(c)), used to monitor and diagnose diabetes, is influenced by average glycemia over a 2- to 3-month period. Genetic factors affecting expression, turnover, and abnormal glycation of hemoglobin could also be associated with increased levels of HbA₁(c). We aimed to ...

Subject

Genome-wide association study

Single-nucleotide polymorphism

Internal medicine

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