A Link between mir-100 and FRAP1/mTOR in Clear Cell Ovarian Cancer

K. Nagaraja, Ankur; J. Creighton, Chad; Yu, Zhifeng; Zhu, Huifeng; H. Gunaratne, Preethi; G. Reid, Jeffrey; Olokpa, Emuejevoke; Itamochi, Hiroaki; T. Ueno, Naoto; M. Hawkins, Shannon; L. Anderson, Matthew; M. Matzuk, Martin

doi:10.1210/me.2009-0295

Public

A Link between mir-100 and FRAP1/mTOR in Clear Cell Ovarian Cancer

Published in Molecular Endocrinology • Jan 16, 2010

Authors:

Ankur K. Nagaraja

Chad J. Creighton

Zhifeng Yu

Abstract

MicroRNAs (miRNAs) are small noncoding RNAs that direct gene regulation through translational repression and degradation of complementary mRNA. Although miRNAs have been implicated as oncogenes and tumor suppressors in a variety of human cancers, functional roles for individual miRNAs have not been ...

Subject

Biology

Oncogene

PI3K/AKT/mTOR pathway

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